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KMID : 0895419930030020166
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Journal of Korean Society of Occupational and Enviromental Hygiene
1993 Volume.3 No. 2 p.166 ~ p.176
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NAG Activity and Urinary Excretion of Hioouric Acid Among Workers Exposed to Aromatic Organic Solvents
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Abstract
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In order to investigate the renal dysfunction in workers exposed to aromatic organic solvents, 105 male exposed workers and 109 controls were participated in this study. This study was conducted to examine the correlation among the concentration of aromatic organic solvents in air, worker´s urinary NAG activity and urinary hippuric acid.
The results were as follows :
1. The exposure level of aromatic organic solvent mixture caculated by the equation proposed by ACGIH was ranged from 0.27 to 0.54 and toluene concentration was ranged from 18.3ppm to 48.3ppm.
2. NAG activity in the urine of control and exposed group were 36.1±14.2nmo1 MU/㎎ creatinine and 52.4±26.1nmo1MU/㎎ creatinine, respectively. Hippuric acid concentration in the urine of control and exposed group were 191.1±194.2㎎/g creatinine and 789.3±784.1㎎/g creatinine, respectively.
3. Correlation coefficient between the exposure level of aromatic organic solvent mixture was significantly related to urinary NAG activity(r=0.542) and urinary hippuric acid(r =0.752).
4. Correlation coefficient between NAG activity and hippuric acid concentration was 0.357.
This study suggested that urinary NAG activity was a good renal function index for aromatic organic solvents exposure and urinary hippuric acid was an index for the biological monitoring of toluene exposure.
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